Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27841122 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2CA12CA9 | |
| SCHEMBL27858668 | 0.82 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL27858835 | 0.79 | CYP2C9 (0.51) | KDM4EALDH1A1GAALMNAKMT2A | |
| SCHEMBL27858592 | 0.78 | ALDH1A1 (0.46) | KDM4EALDH1A1GAAKMT2AMAPT | |
| SCHEMBL27858578 | 0.77 | MBOAT4 (0.38) | KMT2AMAPTMEN1MAPK10 | |
| SCHEMBL27858580 | 0.77 | DAO (0.41) | KDM4EALDH1A1LMNAATMKMT2A | |
| SCHEMBL27841077 | 0.76 | PTGDR2 (0.43) | ATMKCNH2 | |
| SCHEMBL27858676 | 0.75 | COMT (0.46) | KDM4EALDH1A1GAAATMKMT2A | |
| SCHEMBL11099626 | 0.74 | SMN1; SMN2 (0.58) | KDM4EALDH1A1GAALMNAATM | |
| SCHEMBL27858552 | 0.73 | KMT2A (0.45) | GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102264740-B | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators | FIBROGEN, INC. (US) | 2014-10-15 | — | — | CN | disclosed |
| CN-102264740-A | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators | — | 2011-11-30 | — | — | CN | disclosed |