Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 4/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786323 | 0.91 | PGR (0.45) | PGRNOS2TDP2PIK3CD | |
| SCHEMBL2786310 | 0.88 | PGR (0.46) | PGRPIK3CD | |
| SCHEMBL2785070 | 0.88 | PGR (0.46) | PGRTDP2PIK3CD | |
| SCHEMBL2785604 | 0.86 | PGR (0.50) | PGRPIK3CD | |
| SCHEMBL2785545 | 0.83 | PGR (0.46) | PGRPIK3CD | |
| SCHEMBL2787876 | 0.77 | HDAC1 (0.35) | PGRPIK3CD | |
| SCHEMBL2785852 | 0.77 | PGR (0.41) | PGRTDP2PIK3CD | |
| SCHEMBL3016234 | 0.77 | PGR (0.77) | PGRPIK3CD | |
| SCHEMBL2786464 | 0.73 | PGR (0.39) | PGRTDP2PIK3CD | |
| SCHEMBL8808686 | 0.73 | PGR (0.41) | PGRNOS2BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |