Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787557 | 0.90 | KCNA5 (0.47) | MAPTKDM4EIDO1KCNA5HIF1A | |
| SCHEMBL2785205 | 0.87 | ALDH1A1 (0.38) | MAPTKDM4EHIF1AALDH1A1MEN1 | |
| SCHEMBL2787017 | 0.83 | MAPT (0.43) | MAPTKDM4EHIF1AALDH1A1MEN1 | |
| SCHEMBL2787210 | 0.81 | KIT (0.41) | MAPTKDM4EHIF1AALDH1A1HSD17B10 | |
| SCHEMBL2785719 | 0.79 | AURKB (0.42) | MAPTKDM4EIDO1ALDH1A1LMNA | |
| SCHEMBL2785840 | 0.79 | NOX1 (0.36) | MAPTKDM4EHIF1AALDH1A1LMNA | |
| SCHEMBL2784439 | 0.78 | KIT (0.39) | MAPTKDM4EHIF1AALDH1A1LMNA | |
| SCHEMBL2783769 | 0.78 | USP2 (0.36) | MAPTKDM4EHIF1AALDH1A1MEN1 | |
| SCHEMBL2784783 | 0.77 | MAPT (0.39) | MAPTKDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL2785125 | 0.76 | MAPT (0.35) | MAPTKDM4EHIF1AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |