Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.36 |
| ▸ | JUN | P05412 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177654 | 0.75 | MAPT (0.48) | LMNAKDM4EALOX15MAPTTP53 | |
| SCHEMBL10386050 | 0.72 | SLC6A4 (0.46) | LMNAKDM4EALOX15MAPTHTR1A | |
| SCHEMBL9209421 | 0.65 | HTR1D (0.54) | HTR1A | |
| SCHEMBL9213179 | 0.63 | HTR2A (0.60) | HTR1AHTR6DRD2HTR2A | |
| SCHEMBL9213064 | 0.63 | HTR3E (0.45) | LMNAKDM4EMAPTHTR1APOLB | |
| SCHEMBL9213687 | 0.63 | MAPT (0.49) | LMNAKDM4EALOX15MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL9214057 | 0.62 | HTR2A (0.58) | HTR1AHTR6DRD2HTR2A | |
| SCHEMBL9206729 | 0.62 | SLC6A4 (0.52) | KDM4EMAPTHTR1ASLC6A4HTR6 | |
| SCHEMBL9216580 | 0.62 | SLC6A4 (0.48) | HTR1ASLC6A4HTR6DRD2HTR2A | |
| SCHEMBL9211981 | 0.62 | HTR1A (0.67) | HTR1AHTR6DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102656162-A | Novel (heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors | SANOFI SA | 2012-09-05 | — | — | CN | claimed |
| CN-102656162-A | Novel (heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors | SANOFI SA | 2012-09-05 | — | — | CN | disclosed |