Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767332 | 0.75 | GAA (0.47) | CHRNA7LCKGAA | |
| SCHEMBL2767333 | 0.68 | TP53 (0.42) | CHRNA7SCN9AL3MBTL1 | |
| SCHEMBL2787333 | 0.67 | SMN1; SMN2 (0.45) | CHRNA7NPSR1L3MBTL1 | |
| SCHEMBL9512456 | 0.65 | GAA (0.71) | CHRNA7MAOBGAAL3MBTL1 | |
| SCHEMBL2786321 | 0.64 | TP53 (0.44) | CHRNA7 | |
| SCHEMBL2786357 | 0.63 | SMN1; SMN2 (0.41) | MAOBGAA | |
| SCHEMBL9037897 | 0.63 | GAA (0.66) | CHRNA7PDK1PDK2PDK3PDK4 | |
| SCHEMBL8421171 | 0.63 | PDK1 (0.54) | CHRNA7PDK1PDK2PDK3PDK4 | |
| SCHEMBL11402399 | 0.62 | PDK1 (0.59) | CHRNA7LCKPDK1PDK2PDK3 | |
| SCHEMBL7124248 | 0.62 | ACHE (0.41) | CHRNA7MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |