Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788178 | 0.80 | KDM4E (0.53) | KMT2AMEN1MAPK1LMNATSHR | |
| SCHEMBL2770355 | 0.79 | SMN1; SMN2 (0.49) | RAB9AHPGDALDH1A1 | |
| SCHEMBL2786524 | 0.72 | HIF1A (0.40) | KMT2AMEN1LMNATSHRRAB9A | |
| SCHEMBL2786203 | 0.71 | MAPT (0.48) | KMT2AMEN1RAB9AHPGDHSD17B10 | |
| SCHEMBL2785389 | 0.68 | LMNA (0.38) | KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL2787412 | 0.66 | GAA (0.47) | KMT2AMEN1RAB9AHPGDNPC1 | |
| SCHEMBL2787572 | 0.64 | MAPT (0.38) | KMT2AMEN1MAPK1LMNA | |
| SCHEMBL10120105 | 0.64 | ALDH2 (0.72) | KMT2AMEN1MAPK1LMNAMMP13 | |
| Cyclohexane SCHEMBL2442882 | 0.64 | KCNA5 (0.39) | KMT2AMEN1LMNATSHR | |
| SCHEMBL5121760 | 0.64 | SGMS2 (0.36) | KMT2AMEN1HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |