Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.44 |
| ▸ | KIF5B | P33176 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | METTL3 | Q86U44 | 10/20 | 0.41 |
| ▸ | ADK | P55263 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28799602 | 0.88 | ADK (0.41) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL1442891 | 0.78 | RET (0.46) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL1444002 | 0.77 | RET (0.69) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL1444001 | 0.77 | RET (0.69) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL27864236 | 0.76 | RET (0.52) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL18925745 | 0.75 | METTL3 (0.50) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL16769693 | 0.75 | METTL3 (0.50) | RETKIF5BKDRMETTL3ADK | |
| SCHEMBL869590 | 0.74 | ADK (0.53) | RETKDRMETTL3ADKABL1 | |
| SCHEMBL23854926 | 0.73 | SRC (0.59) | RETKDRADKABL1NTRK1 | |
| SCHEMBL23854924 | 0.73 | SRC (0.59) | RETKDRADKABL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596963-A | Ether derivatives of bicyclic heteroaryls | NOVARTIS AG | 2012-07-18 | — | — | CN | disclosed |