Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | BAX | Q07812 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL28343577 | 0.96 | AKR1C3 (0.46) | AKR1C3LTA4HTSHRSOS1CA1 | |
| Diphenylether SCHEMBL27771097 | 0.90 | LTA4H (0.55) | AKR1C3LTA4HTSHRCA1CA2 | |
| Diphenylether SCHEMBL27491160 | 0.89 | LTA4H (0.60) | AKR1C3LTA4HTSHRCA1CA2 | |
| Diphenylether SCHEMBL28263293 | 0.87 | LTA4H (0.57) | AKR1C3LTA4HTSHRCA1CA2 | |
| Sulfuric Acid SCHEMBL28371938 | 0.87 | KMT2A (0.50) | TSHRCA1CA2CA9HTT | |
| SCHEMBL29110245 | 0.85 | PARP10 (0.55) | AKR1C3LTA4HTSHRCA1CA2 | |
| Sulfuric Acid SCHEMBL29012304 | 0.85 | KMT2A (0.48) | TSHRCA1CA2CA9HTT | |
| Diphenylether SCHEMBL9010428 | 0.85 | LTA4H (0.60) | AKR1C3LTA4HTSHRSOS1CA1 | |
| Diphenylether SCHEMBL387430 | 0.85 | LTA4H (0.67) | AKR1C3LTA4HTSHRSOS1CA1 | |
| Diphenylether SCHEMBL8662108 | 0.85 | LTA4H (0.67) | AKR1C3LTA4HTSHRSOS1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101668784-B | Emulsion for damping member | NIPPON CATALYTIC CHEM IND | 2012-07-18 | — | — | CN | claimed |
| CN-101668784-A | Emulsion for damping member | NIPPON CATALYTIC CHEM IND | 2010-03-10 | — | — | CN | claimed |
| CN-106752694-A | A kind of Industrial Heritage steel construction basic unit protective agent and its preparation method and application | 中国京冶工程技术有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106700825-A | Long term comprehensive protection method for steel structure of industrial heritage | 中国京冶工程技术有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-106675324-A | Intermediate layer binder for steel structure of industrial heritages and preparation method and application of intermediate layer binder | 中国京冶工程技术有限公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-106634417-A | Industrial heritage structural structure surface layer protection agent, as well as preparation method and application thereof | 中国京冶工程技术有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-103540193-B | Ink composition, inkjet recording method, and printed matter | RICOH CO LTD | 2015-06-03 | — | — | CN | disclosed |
| CN-103666106-A | INKJET INK, INK CARTRIDGE, INKJET RECORDING DEVICE, AND INKJET PRINTED MATTER | RICOH CO LTD | 2014-03-26 | — | — | CN | disclosed |
| CN-103540193-A | Ink composition, inkjet recording method, and printed matter | RICOH CO LTD | 2014-01-29 | — | — | CN | disclosed |
| CN-102803410-A | Ink for inkjet recording, inkjet recording method using the same, ink cartridge housing the same, and recorded matter | RICOH CO LTD | 2012-11-28 | — | — | CN | disclosed |
| CN-101668784-B | Emulsion for damping member | NIPPON CATALYTIC CHEM IND | 2012-07-18 | — | — | CN | disclosed |
| CN-101668784-A | Emulsion for damping member | NIPPON CATALYTIC CHEM IND | 2010-03-10 | — | — | CN | disclosed |