Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.31 |
| ▸ | PPARA | Q07869 | 6/20 | 0.31 |
| ▸ | PPARD | Q03181 | 5/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884203 | 0.87 | PPARG (0.34) | PPARGPPARAPPARDCACNA1HGRIK1 | |
| SCHEMBL27884309 | 0.83 | PPARG (0.32) | PPARGPPARAPPARDP2RX3CACNA1H | |
| SCHEMBL28797215 | 0.81 | DHCR7 (0.41) | PPARGPPARAPPARDGRIK1GRIK2 | |
| SCHEMBL28946031 | 0.80 | ACLY (0.35) | PPARGPPARAPPARDGRIK1GRIK2 | |
| SCHEMBL27867731 | 0.80 | CCR2 (0.43) | PPARGPPARAPPARDACLY | |
| SCHEMBL27884298 | 0.77 | PPARG (0.36) | PPARGPPARAPPARD | |
| SCHEMBL27713455 | 0.76 | PPARG (0.54) | PPARGPPARAPPARDACLYSMN1; SMN2 | |
| SCHEMBL27733850 | 0.75 | PPARG (0.56) | PPARGPPARAPPARD | |
| SCHEMBL27884471 | 0.74 | ACLY (0.37) | PPARGPPARAPPARDACLY | |
| SCHEMBL27867734 | 0.73 | CCR2 (0.39) | PPARGPPARAPPARDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |