Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 8/20 | 0.37 |
| ▸ | PPARA | Q07869 | 7/20 | 0.37 |
| ▸ | PPARD | Q03181 | 6/20 | 0.37 |
| ▸ | RORC | P51449 | 4/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884298 | 0.93 | PPARG (0.36) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL28800059 | 0.92 | PPARG (0.36) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL28800067 | 0.89 | RORC (0.40) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL28807364 | 0.86 | PPARG (0.38) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL12096783 | 0.85 | PPARG (0.53) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL28946335 | 0.85 | PPARG (0.36) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL27867730 | 0.84 | PPARG (0.41) | CCR2PPARGPPARAPPARDRORC | |
| SCHEMBL27884203 | 0.84 | PPARG (0.34) | CCR2PPARGPPARAPPARD | |
| SCHEMBL28946031 | 0.83 | ACLY (0.35) | PPARGPPARAPPARDMEN1KMT2A | |
| SCHEMBL27867800 | 0.83 | PPARG (0.38) | PPARGPPARAPPARDRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |