Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 5/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARD | Q03181 | 4/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27884471 | 0.92 | ACLY (0.37) | DHCR7PHGDHACLYPPARGPPARD | |
| SCHEMBL27867731 | 0.91 | CCR2 (0.43) | PHGDHACLYPPARGPPARDPPARA | |
| SCHEMBL27884364 | 0.89 | DHCR7 (0.42) | DHCR7ACLYEBPSIGMAR1PPARG | |
| SCHEMBL28800067 | 0.88 | RORC (0.40) | DHCR7PPARGPPARDPPARA | |
| SCHEMBL28946031 | 0.88 | ACLY (0.35) | DHCR7PHGDHACLYPPARGPPARD | |
| SCHEMBL27884203 | 0.88 | PPARG (0.34) | DHCR7PHGDHACLYPPARGPPARD | |
| SCHEMBL27884355 | 0.88 | PPARG (0.44) | DHCR7ACLYEBPSIGMAR1PPARG | |
| SCHEMBL27867728 | 0.87 | ACLY (0.39) | DHCR7ACLYEBPSIGMAR1PPARG | |
| SCHEMBL27884477 | 0.84 | PHGDH (0.44) | DHCR7PHGDHACLYEBPSIGMAR1 | |
| SCHEMBL27713455 | 0.84 | PPARG (0.54) | ACLYPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |