Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.48 |
| ▸ | CYBB | P04839 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.48 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31657639 | 0.92 | NOX1 (0.55) | GAANOX1MAPTMEN1KMT2A | |
| SCHEMBL1719765 | 0.92 | NOX1 (0.55) | GAANOX1MAPTMEN1KMT2A | |
| Benzene SCHEMBL28125613 | 0.84 | ALOX5 (0.54) | GAANOX1MAPTMEN1KMT2A | |
| SCHEMBL293434 | 0.84 | ALOX5 (0.54) | GAANOX1MAPTMEN1KMT2A | |
| SCHEMBL27607313 | 0.81 | NOX1 (0.55) | GAANOX1MAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL31496675 | 0.81 | NOX1 (0.65) | GAANOX1MAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL31496630 | 0.81 | NOX1 (0.65) | GAANOX1MAPTMEN1KMT2A | |
| SCHEMBL27990168 | 0.80 | GAA (0.43) | GAANOX1MAPTMEN1KMT2A | |
| SCHEMBL547518 | 0.79 | NOX1 (0.48) | GAANOX1MAPTMEN1KMT2A | |
| SCHEMBL5362784 | 0.78 | NOX1 (0.52) | GAANOX1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1330513-A | Low adenosine antisense oligonucleotides, compositions, kits and methods for treating airway disorders associated with bronchoconstriction, pneumonia, allergy and surfactant deficiency | UNIV EAST CAROLINA (US) | 2002-01-09 | — | — | CN | disclosed |
| CN-1317009-A | Low adenosine anti-sense oligonucleotide agent, composition, reagent kit and treatments | UNIV EAST CAROLINA (US) | 2001-10-10 | — | — | CN | disclosed |