Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 4/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27532477 | 0.82 | PNMT (0.35) | PNMTTAAR1DPP4TSHRSMN1; SMN2 | |
| SCHEMBL5704383 | 0.81 | ADRA2A (0.40) | TSHRCHRM2CHRM1CHRM3 | |
| SCHEMBL21176962 | 0.79 | TSHR (0.34) | TAAR1TSHRCHRM2CHRM1CHRM3 | |
| SCHEMBL3197029 | 0.78 | CYSLTR2 (0.43) | TSHR | |
| SCHEMBL11346927 | 0.78 | PNMT (0.38) | PNMTTAAR1DPP4TSHRKDM4E | |
| SCHEMBL473489 | 0.77 | GABRA1 (0.40) | TAAR1TSHRSMN1; SMN2HTR2CHTR2B | |
| SCHEMBL394464 | 0.77 | TSHR (0.55) | PNMTTAAR1DPP4TSHRKDM4E | |
| SCHEMBL28038251 | 0.77 | TYR (0.36) | — | |
| SCHEMBL12290677 | 0.76 | ESR1 (0.42) | TSHRCHRM2CHRM1CHRM3KDM4E | |
| SCHEMBL27891817 | 0.74 | TAAR1 (0.42) | TAAR1CHRM2CHRM1CHRM3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105503760-A | Crystalline ARB-NEPi dicationic compound and preparation method and application thereof | SHANGHAI HANSOH BIOMEDICAL CO LTD | 2016-04-20 | — | — | CN | claimed |
| CN-108685889-A | Nep inhibitor for treating the disease for being characterized as atrial enlargement or reconstruct | 诺华股份有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-105503760-A | Crystalline ARB-NEPi dicationic compound and preparation method and application thereof | SHANGHAI HANSOH BIOMEDICAL CO LTD | 2016-04-20 | — | — | CN | disclosed |
| CN-102702119-B | The pharmaceutical combination product of angiotensin receptor antagonist and nep inhibitor | NOVARTIS AG (CH) | 2016-01-20 | — | — | CN | disclosed |
| CN-102702119-A | Pharmaceutical combinations of an angiotensin receptor antagonist and an NEP inhibitor | NOVARTIS AG (CH) | 2012-10-03 | — | — | CN | disclosed |