Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PER2 | O15055 | 1/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791810 | 0.79 | USP30 (0.42) | HTR6BCHEACKR3USP30LMNA | |
| SCHEMBL2792403 | 0.75 | PROKR1 (0.49) | HTR6BCHEACKR3USP30KDM1A | |
| SCHEMBL2792273 | 0.73 | CNR2 (0.44) | HTR6BCHEACKR3USP30KDM1A | |
| SCHEMBL2791100 | 0.73 | ANO1 (0.43) | USP30LMNACNR2PROKR1SCN9A | |
| SCHEMBL12198095 | 0.71 | KDM4E (0.44) | PROKR1TP53MAPT | |
| SCHEMBL7900007 | 0.70 | USP30 (0.44) | HTR6BCHEACKR3USP30KDM1A | |
| SCHEMBL31358176 | 0.69 | SCN9A (0.53) | HTR6BCHEACKR3USP30KDM1A | |
| SCHEMBL6359096 | 0.68 | ALDH1A1 (0.56) | ACKR3USP30LMNATP53MAPT | |
| SCHEMBL3002627 | 0.68 | ACKR3 (0.57) | HTR6BCHEACKR3KDM1ASCN9A | |
| SCHEMBL3002618 | 0.68 | ACKR3 (0.57) | HTR6BCHEACKR3KDM1ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |