Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 12/20 | 0.55 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29484542 | 0.77 | ADK (0.54) | ADKSRCRIPK2MTORRAB9A | |
| SCHEMBL16237288 | 0.77 | SRC (0.59) | ADKSRCRIPK2MTORRAB9A | |
| SCHEMBL16236390 | 0.77 | ADK (0.54) | ADKSRCRIPK2MTORRAB9A | |
| SCHEMBL25388583 | 0.76 | YTHDC1 (0.49) | ADKYTHDC1SRCEGFRMAP4K4 | |
| SCHEMBL11926976 | 0.75 | SRC (0.45) | ADKSRCRIPK2MTORRAB9A | |
| SCHEMBL26004210 | 0.73 | YTHDC1 (0.45) | ADKYTHDC1SRCRIPK2MTOR | |
| SCHEMBL17818402 | 0.73 | ADK (0.45) | ADKYTHDC1SRCEGFRLCK | |
| SCHEMBL29588944 | 0.73 | ADK (0.45) | ADKYTHDC1SRCEGFRLCK | |
| SCHEMBL1933264 | 0.72 | RIPK2 (0.63) | ADKSRCRIPK2MTORRAB9A | |
| SCHEMBL1933267 | 0.72 | RIPK2 (0.63) | ADKSRCRIPK2MTORRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924458-B | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC | 2014-11-05 | — | — | CN | disclosed |
| CN-102924458-A | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC | 2013-02-13 | — | — | CN | disclosed |