Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 5/20 | 0.45 |
| ▸ | MMP13 | P45452 | 5/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165779 | 0.91 | MAPK14 (0.50) | MAPK14MMP1MMP13BDKRB1MEN1 | |
| SCHEMBL2787530 | 0.85 | MMP1 (0.51) | MAPK14MMP1MMP13MEN1KMT2A | |
| SCHEMBL765538 | 0.80 | BDKRB1 (0.58) | MAPK14MMP1MMP13BDKRB1MEN1 | |
| SCHEMBL2807955 | 0.80 | L3MBTL1 (0.36) | BDKRB1KMT2AALDH1A1L3MBTL1POLB | |
| SCHEMBL2787450 | 0.80 | L3MBTL1 (0.36) | BDKRB1KMT2AALDH1A1L3MBTL1POLB | |
| SCHEMBL13165798 | 0.79 | BDKRB1 (0.46) | MAPK14BDKRB1ALDH1A1L3MBTL1GSK3B | |
| SCHEMBL756518 | 0.78 | BDKRB1 (0.39) | MAPK14BDKRB1MEN1KMT2ATDP1 | |
| SCHEMBL185942 | 0.78 | FAAH (0.38) | BDKRB1GAAHTTTRPV1POLB | |
| SCHEMBL758571 | 0.77 | BDKRB1 (0.47) | MAPK14BDKRB1MEN1KMT2ATDP1 | |
| SCHEMBL13165826 | 0.77 | BDKRB1 (0.42) | MAPK14MMP1MMP13BDKRB1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |