Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765186 | 0.90 | BDKRB1 (0.58) | BDKRB1CARM1PRMT6MAPK14HRH3 | |
| SCHEMBL756449 | 0.79 | BDKRB1 (0.46) | BDKRB1MAPK14FAAHLMNAALDH1A1 | |
| SCHEMBL184989 | 0.79 | BDKRB1 (0.50) | BDKRB1FAAHTRPV1CYP3A4CYP2C9 | |
| SCHEMBL187120 | 0.78 | BDKRB1 (0.50) | BDKRB1NPC1RAB9AFAAHTRPV1 | |
| SCHEMBL754425 | 0.78 | PPARD (0.44) | BDKRB1CARM1PRMT6FAAHALDH1A1 | |
| SCHEMBL764461 | 0.77 | BDKRB1 (0.61) | BDKRB1MAPK14LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL764458 | 0.77 | BDKRB1 (0.64) | BDKRB1CARM1PRMT6RAB9AMAPK14 | |
| SCHEMBL2789274 | 0.77 | MAPK14 (0.45) | BDKRB1CARM1PRMT6NPC1RAB9A | |
| SCHEMBL14856425 | 0.77 | BDKRB1 (0.48) | BDKRB1NPC1RAB9AFAAHALDH1A1 | |
| SCHEMBL10121331 | 0.77 | BDKRB1 (0.60) | BDKRB1CARM1PRMT6MAPK14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |
| EP-2188254-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027450-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-05 | — | — | WO | disclosed |