Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27911493 | 0.81 | DGAT1 (0.36) | DGAT1PTGDR2AAK1RBP4 | |
| SCHEMBL27911496 | 0.79 | DGAT1 (0.34) | DGAT1PTGDR2AAK1RBP4 | |
| SCHEMBL12614516 | 0.77 | DGAT1 (0.44) | DGAT1PTGDR2AAK1RBP4 | |
| SCHEMBL27698022 | 0.71 | DGAT1 (0.44) | DGAT1AAK1 | |
| SCHEMBL27828850 | 0.70 | RAB9A (0.38) | PTGDR2AAK1 | |
| SCHEMBL27808403 | 0.70 | OGG1 (0.37) | — | |
| SCHEMBL6923396 | 0.70 | DGAT1 (0.36) | DGAT1PTGDR2 | |
| SCHEMBL28228164 | 0.69 | PTGDR2 (0.46) | DGAT1PTGDR2AAK1RBP4 | |
| SCHEMBL245821 | 0.68 | AAK1 (0.48) | PTGDR2AAK1 | |
| SCHEMBL16435370 | 0.68 | AAK1 (0.48) | PTGDR2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102985412-A | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatement of alzheimer's disease and other forms of dementia | JANSSEN PHARMACEUTICA NV | 2013-03-20 | — | — | CN | disclosed |