Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 5/20 | 0.41 |
| ▸ | CDK9 | P50750 | 5/20 | 0.41 |
| ▸ | CCNK | O75909 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904064 | 0.84 | HTR2A (0.40) | CCNT1CDK9CCNKCCNE1CDK2 | |
| SCHEMBL24420526 | 0.69 | GPR84 (0.41) | — | |
| SCHEMBL7901873 | 0.68 | CCNT1 (0.45) | CCNT1CDK9HTR2AHTR2CKCNH2 | |
| SCHEMBL2789844 | 0.67 | SSTR4 (0.35) | CCNT1CDK9CCNKCCNE1CDK2 | |
| SCHEMBL2788485 | 0.65 | CCNT1 (0.51) | CCNT1CDK9HTR2AHTR2CKCNH2 | |
| SCHEMBL26837562 | 0.65 | HTR2A (0.51) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL2145272 | 0.65 | HTR6 (0.45) | HTR2ADRD2DRD3HTR6 | |
| SCHEMBL7898453 | 0.64 | HTR2A (0.57) | CCNT1CDK9CCNKCDK12HTR2A | |
| SCHEMBL16760180 | 0.64 | HTR2A (0.57) | CCNT1CDK9CCNKCDK12HTR2A | |
| SCHEMBL2791447 | 0.64 | CYP2D6 (0.41) | CCNT1CDK9HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |