Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL1896714 | 0.92 | ALDH1A1 (0.44) | ALDH1A1POLB | |
| Tetrahydrofuran SCHEMBL15993933 | 0.92 | ALDH1A1 (0.50) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL3369904 | 0.92 | ALDH1A1 (0.50) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL599386 | 0.90 | ALDH1A1 (0.42) | ALDH1A1POLB | |
| SCHEMBL8530499 | 0.89 | ALDH1A1 (0.47) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL8412489 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TSHRPOLB | |
| Tetrahydrofuran SCHEMBL30232 | 0.86 | — | — | |
| Tetrahydrofuran SCHEMBL241626 | 0.83 | — | — | |
| Alcohol SCHEMBL3138912 | 0.83 | ALDH1A1 (0.53) | ALDH1A1TSHR | |
| Tetrahydrofuran SCHEMBL218583 | 0.83 | ALDH1A1 (0.53) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102775389-B | Preparation method of N-substituted-4-(7-chloro-quinoline -4-amino)-benzamide derivatives, and application thereof | UNIV HUAQIAO | 2014-12-17 | — | — | CN | disclosed |
| CN-102775389-A | Preparation method of N-substituted-4-(7-chloro-quinoline -4-amino)-benzamide derivatives, and application thereof | UNIV HUAQIAO | 2012-11-14 | — | — | CN | disclosed |