Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29219208 | 0.80 | LMNA (0.56) | LMNATSHRMEN1KMT2AKDM4E | |
| SCHEMBL23214505 | 0.80 | MEN1 (0.68) | LMNATSHRMEN1KMT2AKDM4E | |
| SCHEMBL29663966 | 0.80 | MEN1 (0.68) | LMNATSHRMEN1KMT2AKDM4E | |
| SCHEMBL4644027 | 0.79 | BACE1 (0.56) | MEN1KMT2AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL4642607 | 0.78 | MTNR1A (0.48) | LMNAMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL4642055 | 0.78 | TDP1 (0.44) | SMN1; SMN2HSD17B10L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL4641712 | 0.78 | TDP1 (0.42) | LMNAMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL4644023 | 0.78 | ALDH1A1 (0.43) | LMNAMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL4644298 | 0.77 | TDP1 (0.43) | HSD17B10L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL5623889 | 0.77 | MEN1 (0.88) | LMNATSHRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103108871-A | 17a-hydroxylase/c17,20-lyase inhibitors | NOVARTIS AG | 2013-05-15 | — | — | CN | disclosed |