Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 8/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791483 | 0.91 | CNR2 (0.33) | CNR2CFDCTSCDPP4 | |
| SCHEMBL741417 | 0.89 | CFD (0.36) | AKT1SMYD3CFDCDK2CRBN | |
| SCHEMBL741416 | 0.89 | CFD (0.36) | AKT1SMYD3CFDCDK2CRBN | |
| SCHEMBL2789341 | 0.87 | CNR2 (0.37) | CNR2CFDDPP4 | |
| SCHEMBL2789943 | 0.86 | AKT1 (0.36) | AKT1SMYD3CNR2CDK2CTSC | |
| SCHEMBL2791998 | 0.86 | CNR2 (0.35) | CNR2CFDDPP4 | |
| SCHEMBL2792440 | 0.85 | CNR2 (0.36) | CNR2CFDDPP4 | |
| SCHEMBL741966 | 0.84 | AKT1 (0.36) | AKT1SMYD3CFDCDK2CRBN | |
| SCHEMBL742052 | 0.84 | AKT1 (0.36) | AKT1SMYD3CFDCDK2CRBN | |
| SCHEMBL742026 | 0.84 | CFD (0.37) | SMYD3CFDCRBNPADI4CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |