Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL28764497 | 0.84 | ALDH1A1 (0.33) | — | |
| SCHEMBL7601279 | 0.80 | MMP1 (0.32) | MAPK1 | |
| SCHEMBL18404322 | 0.78 | CYP4F2 (0.33) | TSHRHSD17B10KMT2A | |
| SCHEMBL7799639 | 0.77 | TSHR (0.37) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL8837708 | 0.76 | TSHR (0.36) | TSHRMAPK1HSD17B10TDP1THRB | |
| Ethylamine SCHEMBL27752692 | 0.75 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL27539116 | 0.75 | TSHR (0.31) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL29232749 | 0.74 | TSHR (0.35) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL7623339 | 0.74 | TSHR (0.39) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL26103710 | 0.74 | TSHR (0.35) | TSHRMAPK1HSD17B10TDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896482-B | Thiophene derivatives as S1P1/EDG1 agonists | ACTELION PHARMACEUTICALS LTD | 2013-01-09 | — | — | CN | disclosed |