Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL28764497 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL13018296 | 0.66 | MMP1 (0.34) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL9010708 | 0.65 | — | — | |
| SCHEMBL31281258 | 0.65 | — | — | |
| SCHEMBL28399846 | 0.65 | — | — | |
| SCHEMBL31598456 | 0.62 | — | — | |
| SCHEMBL30015491 | 0.61 | — | — | |
| SCHEMBL18404322 | 0.61 | CYP4F2 (0.33) | — | |
| SCHEMBL31381385 | 0.60 | — | — | |
| SCHEMBL13753921 | 0.58 | CTSK (0.68) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229939-A1 | USE OF HISTAMINE AS A DRUG DELIVERY ENHANCING COMPOUND FOR USE IN TRANSMUCOSAL OR TRANSDERMAL DELIVERY | Maxim Pharmaceuticals, Inc. (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001008706-A1 | USE OF HISTAMINE AS A DRUG DELIVERY ENHANCING COMPOUND FOR USE IN TRANSMUCOSAL OR TRANSDERMAL DELIVERY | MAXIM PHARMACEUTICALS, INC. (US) | 2001-02-08 | — | — | WO | disclosed |