Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861729 | 0.82 | MCL1 (0.49) | KDM4EALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL114253 | 0.82 | GAA (0.47) | KDM4EALDH1A1POLBKMT2AMAPT | |
| SCHEMBL9433289 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1POLBKMT2ATEAD1 | |
| SCHEMBL9399721 | 0.77 | SMN1; SMN2 (0.38) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL27917704 | 0.77 | KDM4E (0.40) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL353910 | 0.73 | KCNH2 (0.58) | KDM4EALDH1A1KMT2AMEN1TEAD1 | |
| SCHEMBL2607276 | 0.72 | CYP1A2 (0.47) | KDM4EALDH1A1MAPTAHRSMN1; SMN2 | |
| SCHEMBL9433908 | 0.72 | IRAK4 (0.46) | KDM4EALDH1A1KMT2AMEN1TEAD1 | |
| SCHEMBL27494718 | 0.71 | PTPN1 (0.46) | KMT2AMEN1TEAD1YAP1TEAD4 | |
| SCHEMBL7574372 | 0.69 | CAPN1 (0.54) | KDM4EALDH1A1KMT2AMEN1TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | disclosed |