Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MDH2 | P40926 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KIF20A | O95235 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480455 | 0.85 | GABRP (0.44) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL2788711 | 0.85 | HTT (0.47) | ALDH1A1MEN1KMT2AHTTPRKAB2 | |
| SCHEMBL2793572 | 0.85 | PRKAB2 (0.46) | ALDH1A1MEN1KMT2AHTTPRKAB2 | |
| SCHEMBL2788714 | 0.84 | HTT (0.46) | ALDH1A1MEN1KMT2AHTTPRKAB2 | |
| SCHEMBL2479519 | 0.83 | TRPM8 (0.44) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL2791821 | 0.83 | HTT (0.46) | MEN1KMT2AMAP2K7HTTPRKAB2 | |
| SCHEMBL2787585 | 0.83 | LOXL2 (0.46) | ALDH1A1HPGDMDH2SMN1; SMN2MEN1 | |
| SCHEMBL3693815 | 0.81 | KDR (0.49) | MAP2K7 | |
| SCHEMBL2789507 | 0.81 | HTT (0.46) | ALDH1A1MEN1KMT2AHTTPRKAB2 | |
| SCHEMBL2484090 | 0.81 | HTT (0.46) | MEN1KMT2AHTTPOLBPRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010066684-A2 | Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease | NOVARTIS AG (CH) | 2010-06-17 | — | — | WO | disclosed |