Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27877356 | 0.78 | RECQL (0.41) | — | |
| SCHEMBL27909858 | 0.77 | PNMT (0.44) | PNMTNPC1RAB9AKMT2ACYP3A4 | |
| SCHEMBL27894259 | 0.77 | LMNA (0.37) | CYP3A4SLC6A2SLC6A4CYP1A2CYP2C19 | |
| SCHEMBL27864550 | 0.73 | PNMT (0.62) | PNMTCHRM2CHRM1CHRM3TAAR1 | |
| SCHEMBL27893994 | 0.73 | GABBR2 (0.40) | RAB9AKMT2AHTTSMN1; SMN2 | |
| SCHEMBL14835351 | 0.72 | ACP3 (0.36) | KMT2AHSD17B2SLC6A2SLC6A4SMN1; SMN2 | |
| SCHEMBL29869064 | 0.72 | PNMT (0.55) | PNMTCHRM2CHRM1CHRM3TAAR1 | |
| SCHEMBL11568409 | 0.72 | PNMT (0.55) | PNMTCHRM2CHRM1CHRM3TAAR1 | |
| SCHEMBL27752111 | 0.72 | GABBR2 (0.39) | — | |
| SCHEMBL27909846 | 0.70 | PNMT (0.43) | PNMTCHRM2CHRM1CHRM3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103180296-A | Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer | AMGEN INC | 2013-06-26 | — | — | CN | disclosed |