Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.63 |
| ▸ | RAB9A | P51151 | 14/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | STAT1 | P42224 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11707536 | 0.82 | SMN1; SMN2 (0.81) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL11707531 | 0.82 | SMN1; SMN2 (0.81) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL22658957 | 0.79 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL11704721 | 0.77 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL11704717 | 0.77 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL11701948 | 0.76 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL3273852 | 0.76 | LMNA (0.65) | NPC1RAB9ASMN1; SMN2MAPTSTAT1 | |
| SCHEMBL9756826 | 0.74 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL18985299 | 0.74 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL18985301 | 0.74 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214472-A | Preparation of two novel non-ATP (Adenosine Triphosphate) competitive FGFR1 (Fibroblast Growth Factor Receptor1) inhibitors and anti-tumor activity of two novel non-ATP competitive FGFR1 inhibitors | WENZHOU MEDICAL COLLEGE | 2013-07-24 | — | — | CN | disclosed |