Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 7/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28093912 | 0.89 | SCN3A (0.46) | SCN3ASCN1ASCN5ASCN9ASCN2A | |
| SCHEMBL27913628 | 0.88 | P2RX7 (0.45) | SCN3ASCN1ASCN5ASCN9ASCN2A | |
| SCHEMBL27913866 | 0.86 | CTSD (0.40) | SCN3ASCN5ASCN9AALPLROCK2 | |
| Pyrazinamide SCHEMBL28833282 | 0.85 | SCN3A (0.44) | SCN3ASCN1ASCN5ASCN9ASCN2A | |
| SCHEMBL27913648 | 0.82 | AURKA (0.53) | ROCK2AURKARPS6KB1AURKB | |
| SCHEMBL28093971 | 0.78 | P2RX7 (0.43) | SCN3ASCN1ASCN5ASCN9ASCN2A | |
| SCHEMBL27931776 | 0.76 | VNN1 (0.46) | AKT1AURKARPS6KB1AURKB | |
| SCHEMBL27913577 | 0.76 | VNN1 (0.53) | AURKARPS6KB1AURKB | |
| SCHEMBL27931758 | 0.76 | HDAC3 (0.40) | SCN9AROCK2 | |
| SCHEMBL28833323 | 0.76 | CTSD (0.39) | SCN3ASCN1ASCN5ASCN9ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103249721-A | Arylamine Derivatives as TTX-S Blockers | RAQUALIA PHARMA INC | 2013-08-14 | — | — | CN | claimed |
| CN-103249721-A | Arylamine Derivatives as TTX-S Blockers | RAQUALIA PHARMA INC | 2013-08-14 | — | — | CN | disclosed |