Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Pyrazinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazinamide SCHEMBL28833290 | 0.89 | P2RX7 (0.43) | SCN3ANPC1RAB9AL3MBTL1KCNH2 | |
| Pyrazinamide SCHEMBL28093929 | 0.87 | ADORA3 (0.42) | NPC1RAB9AL3MBTL1SCN5ASCN9A | |
| SCHEMBL27913624 | 0.85 | SCN3A (0.48) | SCN3ACSF1RNPC1RAB9ASCN10A | |
| Pyrazinamide SCHEMBL28093953 | 0.83 | MEN1 (0.49) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL28093912 | 0.80 | SCN3A (0.46) | SCN3ASCN10ASCN1ASCN5ASCN9A | |
| Pyrazinamide SCHEMBL28093431 | 0.78 | KDM4E (0.41) | NPC1RAB9AADORA3TSHRMC4R | |
| Pyrazinamide SCHEMBL28093530 | 0.78 | ADORA3 (0.45) | NPC1RAB9AADORA3TSHRMC4R | |
| Pyrazinamide SCHEMBL28094033 | 0.78 | VNN1 (0.48) | ADORA3TSHRMC4RADRA1AMC3R | |
| Pyrazinamide SCHEMBL28093440 | 0.77 | POLB (0.43) | NPC1RAB9AL3MBTL1SCN10ASCN9A | |
| Pyrazinamide SCHEMBL28093966 | 0.75 | RAB9A (0.47) | NPC1RAB9AL3MBTL1SCN10AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478497-A | Aryl amine derivatives as TTX S blocker | 拉夸里亚创药株式会社 | 2017-03-08 | — | — | CN | claimed |
| CN-106478497-A | Aryl amine derivatives as TTX S blocker | 拉夸里亚创药株式会社 | 2017-03-08 | — | — | CN | disclosed |
| CN-103249721-B | Arylamine Derivatives as TTX-S Blockers | 拉夸里亚创药株式会社 | 2016-10-12 | — | — | CN | disclosed |