Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10257082 | 0.97 | LMNA (0.40) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| Hydrochloric Acid SCHEMBL12482650 | 0.87 | LMNA (0.44) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| SCHEMBL15096156 | 0.84 | LMNA (0.47) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| Hydrochloric Acid SCHEMBL27898310 | 0.80 | LMNA (0.38) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| Hydrochloric Acid SCHEMBL35525 | 0.78 | MAPT (0.50) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| Hydrochloric Acid SCHEMBL1405424 | 0.78 | LMNA (0.47) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| Hydrochloric Acid SCHEMBL9819532 | 0.78 | MAPT (0.50) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| SCHEMBL14958465 | 0.78 | LMNA (0.47) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| Hydrochloric Acid SCHEMBL21409451 | 0.78 | PSMD14 (0.36) | PSMD14PLA2G1BMMP2RAD52ATG4B | |
| SCHEMBL3456928 | 0.77 | LMNA (0.40) | PSMD14PLA2G1BMMP2RAD52ATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103045224-B | Preparation method of viscous oil viscosity reducer containing quaternary ammonium salt structure | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-10-01 | — | — | CN | claimed |
| CN-103045224-A | Preparation method of viscous oil viscosity reducer containing quaternary ammonium salt structure | UNIV SHAANXI SCIENCE & TECH | 2013-04-17 | — | — | CN | claimed |
| CN-103045224-B | Preparation method of viscous oil viscosity reducer containing quaternary ammonium salt structure | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-10-01 | — | — | CN | disclosed |
| CN-103045224-A | Preparation method of viscous oil viscosity reducer containing quaternary ammonium salt structure | UNIV SHAANXI SCIENCE & TECH | 2013-04-17 | — | — | CN | disclosed |