Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14958465 | 1.00 | LMNA (0.47) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| Water SCHEMBL11721226 | 0.97 | LMNA (0.44) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| SCHEMBL15099704 | 0.89 | LMNA (0.38) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| Hydrochloric Acid SCHEMBL27898310 | 0.89 | LMNA (0.38) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| Hydrochloric Acid SCHEMBL9819532 | 0.88 | MAPT (0.50) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| Hydrochloric Acid SCHEMBL35525 | 0.88 | MAPT (0.50) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| SCHEMBL15093781 | 0.87 | ALDH1A1 (0.36) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| SCHEMBL3456928 | 0.86 | LMNA (0.40) | LMNAALDH1A1MAPTTHRBPSMD14 | |
| Hydrochloric Acid SCHEMBL27714839 | 0.85 | PSMD14 (0.47) | LMNAALDH1A1MAPTPSMD14PLA2G1B | |
| Hydrochloric Acid SCHEMBL12482650 | 0.85 | LMNA (0.44) | LMNAALDH1A1MAPTTHRBPSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648025-B2 | Personal care compositions with silicones and polyhydroxy quaternary ammonium salts | CONOPCO, INC. (US) | 2014-02-11 | — | — | US | claimed |
| US-8496916-B2 | Sunscreen composition with polyhydroxy quaternary ammonium salts | CONOPCO, INC. (US) | 2013-07-30 | — | — | US | claimed |
| WO-2013076148-A2 | PERSONAL CARE COMPOSITIONS WITH ENHANCED FRAGRANCE DELIVERY VIA POLYHYDROXY QUATERNARY AMMONIUM SALTS | UNILEVER PLC (GB) | 2013-05-30 | — | — | WO | claimed |
| WO-2013076147-A2 | PERSONAL CARE COMPOSITIONS WITH SILICONES AND POLYHYDROXY QUATERNARY AMMONIUM SALTS | UNILEVER PLC (GB) | 2013-05-30 | — | — | WO | claimed |
| WO-2013076149-A2 | SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS | UNILEVER PLC (GB) | 2013-05-30 | — | — | WO | claimed |
| US-20130129644-A1 | SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS | CONOPCO, INC., D/B/A UNILEVER (US) | 2013-05-23 | — | — | US | claimed |
| US-20130129645-A1 | Personal Care Compositions with Silicones and Polyhydroxy Quaternary Ammonium Salts | CONOPCO, INC., D/B/A UNILEVER (US) | 2013-05-23 | — | — | US | claimed |
| CN-104010621-B | Sunscreen composition with polyhydroxy quaternary ammonium salts | 荷兰联合利华有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-104010621-A | Sunscreen composition with polyhydroxy quaternary ammonium salts | UNILEVER NV | 2014-08-27 | — | — | CN | disclosed |
| US-8648025-B2 | Personal care compositions with silicones and polyhydroxy quaternary ammonium salts | CONOPCO, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| WO-2013076149-A3 | SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS | UNILEVER PLC (GB) | 2013-12-27 | — | — | WO | disclosed |
| US-8496916-B2 | Sunscreen composition with polyhydroxy quaternary ammonium salts | CONOPCO, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8496916-B2 | Sunscreen composition with polyhydroxy quaternary ammonium salts | CONOPCO, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2013076148-A2 | PERSONAL CARE COMPOSITIONS WITH ENHANCED FRAGRANCE DELIVERY VIA POLYHYDROXY QUATERNARY AMMONIUM SALTS | UNILEVER PLC (GB) | 2013-05-30 | — | — | WO | disclosed |
| US-20130129645-A1 | Personal Care Compositions with Silicones and Polyhydroxy Quaternary Ammonium Salts | CONOPCO, INC., D/B/A UNILEVER (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130129644-A1 | SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS | CONOPCO, INC., D/B/A UNILEVER (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130129644-A1 | SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS | CONOPCO, INC., D/B/A UNILEVER (US) | 2013-05-23 | — | — | US | disclosed |
| US-8217201-B2 | Process for preparing quaternary alkammonium halides | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-07-10 | — | — | US | disclosed |
| EP-2054371-B1 | PROCESS FOR PREPARING QUATERNARY ALKYLAMMONIUM HALIDES | DOW GLOBAL TECHNOLOGIES INC (US) | 2011-03-09 | — | — | EP | disclosed |
| US-20100160684-A1 | PROCESS FOR PREPARING QUATERNARY ALKAMMONIUM HALIDES | DOW GLOBAL TECHNOLOGIES LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130129644-A1 | SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS | MMS19, RAD23B, DDAH1 | LMNA 2808/4885ALDH1A1 1939/4885MAPT 2376/4885 |
| US-20130129645-A1 | Personal Care Compositions with Silicones and Polyhydroxy Quaternary Ammonium Salts | CUTA, TAF1, KAT2A | LMNA 3806/4885ALDH1A1 4564/4885MAPT 2630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.