SCHEMBL27915985

SCHEMBL27915985

O=C(O)C1=NOC(c2ccccc2)(c2cccc(F)c2F)C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
HDAC4 P56524 3/20 0.37
HDAC6 Q9UBN7 2/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
POLB P06746 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
CRBN Q96SW2 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
KDM4E B2RXH2 1/20 0.31
CES2 O00748 1/20 0.31
BCHE P06276 1/20 0.31
CES1 P23141 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
MAOA P21397 1/20 0.30
BLVRB P30043 1/20 0.30
ORAI1 Q96D31 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL135288 0.82 AKR1C1 (0.35) CA1CA2HDAC4POLBHCAR2
SCHEMBL1832298 0.80 PTGDR2 (0.38) CA1CA2POLBHCAR2
Isopropylamine SCHEMBL28970090 0.74 ALDH1A1 (0.34) HCAR2KDM4E
SCHEMBL31621764 0.71 KAT6A (0.42) CA1CA2KDM4E
SCHEMBL29498824 0.70 LDHA (0.36) CA1CA2HDAC4HDAC9NPC1
SCHEMBL28574647 0.70 POLB (0.35) CA1CA2HDAC4POLBHDAC9
SCHEMBL12971595 0.69 HDAC4 (0.31) HDAC4
SCHEMBL31501097 0.67 MEN1 (0.37) POLBHCAR2HDAC9KDM4ENPC1
SCHEMBL31501098 0.67 MEN1 (0.37) POLBHCAR2HDAC9KDM4ENPC1
SCHEMBL7167294 0.67 MAPT (0.45) KDM4ERAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103429578-A Herbicide safener composition BAYER IP GMBH 2013-12-04 CN disclosed
CN-103270034-A NOVEL SUBSTITUTED PICOLINIC ACIDS, SALTS AND ACID DERIVATIVES THEREOF, AND USE THEREOF AS HERBICIDES BAYER IP GMBH 2013-08-28 CN disclosed