Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | USP14 | P54578 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27921139 | 0.84 | USP14 (0.52) | PLA2G2ANOTUMHDAC6GAAALDH1A1 | |
| SCHEMBL27794789 | 0.80 | ABCB1 (0.50) | PLA2G2ANOTUMALDH1A1ABCB1PTGS1 | |
| SCHEMBL15435845 | 0.77 | KDM4E (0.59) | NOTUMGAAALDH1A1MAPTKDM4E | |
| SCHEMBL27939667 | 0.75 | HDAC6 (0.52) | PLA2G2AHDAC6ALDH1A1MAPTUSP14 | |
| SCHEMBL18522571 | 0.72 | KDM4E (0.46) | NOTUMGAAALDH1A1MAPTKDM4E | |
| SCHEMBL6941575 | 0.72 | KDM4E (0.53) | GAAALDH1A1MAPTKDM4E | |
| SCHEMBL3969842 | 0.72 | GPR3 (0.56) | GAAALDH1A1MAPTKDM4E | |
| SCHEMBL996292 | 0.70 | ABCB1 (0.50) | PLA2G2AHDAC6ALDH1A1MAPTABCB1 | |
| SCHEMBL23571976 | 0.69 | KDM4E (0.48) | NOTUMGAAALDH1A1MAPTKDM4E | |
| SCHEMBL30815920 | 0.68 | KDM4E (0.52) | GAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360422-B | Oncogenic Ras-specific cytotoxic compound and methods of usethereof | UNIV TEXAS | 2013-10-23 | — | — | CN | claimed |