Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 8/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.38 |
| ▸ | CBFB | Q13951 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27939667 | 0.85 | HDAC6 (0.52) | USP14HDAC6PLA2G2ARORCMAPT | |
| SCHEMBL27921138 | 0.84 | PLA2G2A (0.49) | USP14HDAC6PLA2G2AABCB1PTGS1 | |
| SCHEMBL18235058 | 0.77 | USP14 (0.70) | USP14RORC | |
| SCHEMBL28785169 | 0.77 | ABCB1 (0.58) | USP14HDAC6PLA2G2AABCB1PTGS1 | |
| SCHEMBL3969842 | 0.75 | GPR3 (0.56) | GAAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL19298011 | 0.74 | USP14 (0.70) | USP14RORC | |
| SCHEMBL12546471 | 0.74 | KDM4E (0.67) | USP14GAAMAPTMEN1NPC1 | |
| SCHEMBL31045466 | 0.74 | KDM4E (0.67) | USP14GAAMAPTMEN1NPC1 | |
| SCHEMBL18235059 | 0.73 | NPSR1 (0.50) | USP14RORCMAPTMEN1KMT2A | |
| SCHEMBL18235061 | 0.72 | USP14 (0.66) | USP14RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360422-B | Oncogenic Ras-specific cytotoxic compound and methods of usethereof | UNIV TEXAS | 2013-10-23 | — | — | CN | claimed |