Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5296032 | 0.93 | MAPT (0.55) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7468895 | 0.88 | P4HTM (0.55) | TBXAS1P4HTMFFAR1LMNAL3MBTL1 | |
| SCHEMBL2434548 | 0.85 | KDM4E (0.38) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7209273 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL30227184 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL13851659 | 0.76 | TBXAS1 (0.56) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL13965559 | 0.76 | L3MBTL1 (0.49) | FFAR1TSHRL3MBTL1 | |
| SCHEMBL7017455 | 0.75 | GABRP (0.52) | SMN1; SMN2HSD17B10MAPTP4HTMKDM4E | |
| Cyclopropane SCHEMBL11659767 | 0.75 | EGLN1 (0.48) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL31639573 | 0.74 | MAPT (0.55) | SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103347864-A | For treating diseases caused by Lp-PLA2Pyrimidone compounds for mediated diseases or conditions | GLAXO GROUP LTD | 2013-10-09 | — | — | CN | disclosed |