Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11300280 | 0.87 | OPRL1 (0.47) | OPRL1HTR1ASLC6A2SLC6A4SLC6A3 | |
| Tert-Butyl Formate SCHEMBL27944993 | 0.82 | ADRB1 (0.37) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL11306515 | 0.80 | ADRB1 (0.44) | OPRL1HTR1ASLC6A2SLC6A4SLC6A3 | |
| Tert-Butyl Formate SCHEMBL27925824 | 0.78 | ADRB1 (0.40) | HTR1AHTR6 | |
| SCHEMBL15755266 | 0.78 | ACHE (0.46) | ALDH1A1SMN1; SMN2HPGDL3MBTL1LMNA | |
| Tert-Butyl Formate SCHEMBL27944980 | 0.77 | HTR6 (0.38) | SLC6A2SLC6A4HTR6ALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27944987 | 0.76 | MAPT (0.39) | OPRL1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27925821 | 0.75 | GRM5 (0.39) | ALDH1A1SMN1; SMN2HPGDL3MBTL1LMNA | |
| Tert-Butyl Formate SCHEMBL28256677 | 0.75 | USP28 (0.42) | OPRL1HTR1ASLC6A2SLC6A4HTR6 | |
| Tert-Butyl Formate SCHEMBL27656325 | 0.72 | HTR6 (0.48) | HTR1AHTR6ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443102-A | Bicyclic carboxamide inhibitors of kinases | ABBVIE INC | 2013-12-11 | — | — | CN | disclosed |
| CN-103415516-A | Bicyclic inhibitors of ALK | ABBOTT LAB | 2013-11-27 | — | — | CN | disclosed |