Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.35 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895210 | 0.84 | PTGS2 (0.46) | PTGS2GABRA5LMNANPC1TSHR | |
| SCHEMBL28807048 | 0.81 | PTGS2 (0.39) | PTGS2GABRA5SLC5A1SLC5A2LMNA | |
| SCHEMBL27933718 | 0.80 | MAPK1 (0.35) | GABRA5MAPK1PSEN1PSEN2APH1B | |
| SCHEMBL9895924 | 0.79 | RAB9A (0.38) | PTGS2IDO1TDO2LMNANPC1 | |
| SCHEMBL9896578 | 0.76 | LMNA (0.38) | PTGS2LMNANPC1RAB9ABRD4 | |
| SCHEMBL21402163 | 0.76 | PTGS2 (0.40) | PTGS2GABRA5LMNAGAAL3MBTL1 | |
| SCHEMBL9895133 | 0.75 | GABRA5 (0.43) | GABRA5MAPTBRD4BRD2BRD3 | |
| SCHEMBL9895805 | 0.75 | MAP4K4 (0.38) | PTGS2NPC1TSHRRAB9ABRD4 | |
| SCHEMBL9894949 | 0.73 | RAB9A (0.40) | PTGS2GABRA5IDO1TDO2NPC1 | |
| SCHEMBL27915203 | 0.73 | PTGS2 (0.52) | PTGS2GABRA5IDO1TDO2SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103249728-A | Novel triazole compounds III | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | claimed |
| CN-103249728-A | Novel triazole compounds III | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | disclosed |