Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18651951 | 0.73 | KDM4E (0.38) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL7970964 | 0.72 | CHRM2 (0.39) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL2793465 | 0.71 | USP2 (0.37) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL19827493 | 0.70 | GPR119 (0.39) | NR1H2KDM1AGPR119ADORA1USP30 | |
| SCHEMBL3505154 | 0.68 | ESR2 (0.45) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL3629917 | 0.67 | KDM4E (0.39) | CHRM2CHRM1CHRM3GPR119ELANE | |
| SCHEMBL4876240 | 0.67 | KDM4E (0.39) | CHRM2CHRM1CHRM3GPR119ELANE | |
| SCHEMBL29215624 | 0.67 | GAA (0.37) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL3714508 | 0.67 | KDM4E (0.36) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL28311005 | 0.67 | NR1H2 (0.35) | NR1H2GPR119RORCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075199-A | JAK inhibitor compounds and uses thereof | 河南迈英诺医药科技有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-114075200-A | JAK inhibitor compounds for the treatment of severe pneumonia | 河南迈英诺医药科技有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-113563345-A | JAK inhibitor compounds and uses thereof | 河南迈英诺医药科技有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-111606908-B | JAK inhibitor compounds and uses thereof | 河南迈英诺医药科技有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-111606908-A | JAK inhibitor compounds and uses thereof | 河南迈英诺医药科技有限公司 | 2020-09-01 | — | — | CN | disclosed |