Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14060017 | 0.79 | ALDH1A1 (0.40) | CNR1CNR2L3MBTL1 | |
| SCHEMBL14060873 | 0.75 | AR (0.38) | CNR2L3MBTL1 | |
| SCHEMBL14059902 | 0.74 | CYP1A2 (0.47) | HTR6CNR1CNR2ADRA2C | |
| SCHEMBL27953793 | 0.72 | CNR2 (0.52) | CNR2POLB | |
| SCHEMBL14060078 | 0.72 | MEN1 (0.43) | CNR2POLB | |
| SCHEMBL12663049 | 0.72 | L3MBTL3 (0.64) | HRH3HTR6ESR1ESR2ADRA2A | |
| SCHEMBL12498579 | 0.69 | HDAC4 (0.46) | HRH3HTR6ESR1ESR2ADRA2A | |
| SCHEMBL12663092 | 0.68 | MBTD1 (0.61) | HRH3HTR6ESR1ESR2ADRA2A | |
| SCHEMBL17127953 | 0.68 | MBTD1 (0.61) | HRH3HTR6ESR1ESR2ADRA2A | |
| SCHEMBL5924613 | 0.67 | CYP2A6 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |