Methylene Chloride

Methylene Chloride

SCHEMBL27947432

ClCCl.Clc1cc(Cl)ncn1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
RECQL P46063 1/20 0.36
LOX P28300 1/20 0.36
LOXL3 P58215 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.36
NPC1 O15118 1/20 0.34
CDC7 O00311 1/20 0.32
DAPK3 O43293 1/20 0.32
MAP4K4 O95819 1/20 0.32
PIM1 P11309 1/20 0.32
PRKACA P17612 1/20 0.32
FLT3 P36888 1/20 0.32
CDK8 P49336 1/20 0.32
CLK2 P49760 1/20 0.32
GSK3B P49841 1/20 0.32
CDK7 P50613 1/20 0.32
CDK9 P50750 1/20 0.32
PRKX P51817 1/20 0.32
CDK5 Q00535 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31051471 0.90
SCHEMBL28153591 0.87 MEN1 (0.40) MEN1KMT2ARECQLLOXLOXL3
SCHEMBL7982137 0.78
Isopropyl Alcohol SCHEMBL28207243 0.75 NPC1 (0.35) MEN1KMT2ARECQLNPC1
Acetaldehyde SCHEMBL28232456 0.75 NPC1 (0.35) MEN1KMT2ANPC1
Bicarbonate SCHEMBL28202844 0.73 KMO (0.33) MEN1KMT2ARECQLNPC1
Chlorobenzene SCHEMBL27930649 0.73 TSHR (0.55) MEN1KMT2ANPC1MAP4K4CDK7
SCHEMBL1660131 0.71
SCHEMBL14399500 0.71
SCHEMBL28242954 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103450094-B A kind of purification process of 4,6-dichloro pyrimidine CHONGQING UNISPLENDOUR CHEMICAL CO., LTD. (CN) 2015-08-26 CN disclosed
CN-103450094-A Method for purifying 4, 6-dichloro pyrimidine CHONGQING UNISPLENDOUR CHEM CO 2013-12-18 CN disclosed