Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28947564 | 0.94 | RORC (0.39) | RORCPPARGMAPTPOLBCA1 | |
| SCHEMBL28807374 | 0.87 | RORC (0.39) | RORCPPARGKCNN4ALDH1A1HTT | |
| SCHEMBL27950241 | 0.86 | MAPT (0.35) | RORCPPARGMAPTCA1CA2 | |
| SCHEMBL27936033 | 0.85 | RORC (0.41) | RORCPPARGMAPTPOLBCYP3A4 | |
| SCHEMBL27950251 | 0.81 | RORC (0.41) | RORCPPARGCYP3A4CYP2C9MAPK1 | |
| SCHEMBL27936029 | 0.81 | RXRA (0.36) | RORCPPARG | |
| SCHEMBL28809335 | 0.80 | POLB (0.34) | RORCPPARGMAPTPOLBKCNN4 | |
| SCHEMBL27950350 | 0.79 | PPARG (0.35) | RORCPPARGMAPTPOLBKCNN4 | |
| SCHEMBL27950246 | 0.77 | PPARG (0.35) | RORCPPARG | |
| SCHEMBL28807361 | 0.76 | PPARG (0.36) | RORCPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |