Fluorene

Fluorene

SCHEMBL27950409

c1ccc(-c2ccccn2)nc1.c1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.61
LMNA P02545 4/20 0.61
CCR1 P32246 3/20 0.61
CCR5 P51681 3/20 0.61
CCR8 P51685 3/20 0.61
CYP1A2 P05177 3/20 0.61
HIF1A Q16665 2/20 0.61
POLB P06746 1/20 0.61
METAP1 P53582 1/20 0.61
BLM P54132 1/20 0.61
DOHH Q9BU89 1/20 0.61
P4HTM Q9NXG6 1/20 0.61
NPC1 O15118 6/20 0.52
RAB9A P51151 6/20 0.52
TP53 P04637 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
ALDH1A1 P00352 3/20 0.52
ALOX15 P16050 2/20 0.52
HTT P42858 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluorene SCHEMBL27530322 0.94 KDM4E (0.52) KDM4ELMNACCR1CCR5CCR8
Fluorene SCHEMBL28302101 0.85 HTR1A (0.47) KDM4ELMNACCR1CCR5CCR8
SCHEMBL14065143 0.84 PDK2 (0.48) KDM4ELMNACCR1CCR5CCR8
SCHEMBL6130756 0.84 PDK2 (0.51) KDM4ELMNACCR1CCR5CCR8
SCHEMBL483647 0.83 PNMT (0.46) KDM4ELMNACCR1CCR5CCR8
Fluorene SCHEMBL29105566 0.82 MAOA (0.50) KDM4ELMNACYP1A2HIF1APOLB
Fluorene SCHEMBL23387530 0.79 MAOA (0.52) KDM4ELMNACYP1A2NPC1RAB9A
Fluorene SCHEMBL25309211 0.79 MAOA (0.52) KDM4ELMNACYP1A2NPC1RAB9A
Fluorene SCHEMBL27936333 0.79 MAOA (0.52) KDM4ELMNACYP1A2NPC1RAB9A
Fluorene SCHEMBL7575260 0.78 MAOA (0.62) KDM4ELMNACYP1A2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111303015-B Preparation and application of small organic molecule with AIE effect 常州大学 2023-01-31 CN disclosed
CN-111348641-B Method for replacing single-walled carbon nanotube solution system 中国科学院苏州纳米技术与纳米仿生研究所 2022-12-27 CN disclosed
CN-111348641-A Method for replacing single-walled carbon nanotube solution system 中国科学院苏州纳米技术与纳米仿生研究所 2020-06-30 CN disclosed
CN-111303015-A Preparation and application of small organic molecule with AIE effect 常州大学 2020-06-19 CN disclosed
CN-103509016-B Bipyridine fluorene derivatives, preparation method and application thereof, and electroluminescent device TCL GROUP CO LTD 2015-05-20 CN disclosed
CN-103509016-A Bipyridine fluorene derivatives, preparation method and application thereof, and electroluminescent device TCL GROUP CO LTD 2014-01-15 CN disclosed