Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 5/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 7/20 | 0.33 |
| ▸ | FPR3 | P25089 | 6/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704174 | 0.74 | MAPT (0.40) | MAPTNPC1RAB9AKDM1AHRH3 | |
| SCHEMBL2332615 | 0.73 | MAPT (0.40) | MAPTNPC1RAB9AKDM1AHRH3 | |
| SCHEMBL27939524 | 0.72 | RAB9A (0.37) | NPC1RAB9AFPR2FPR3 | |
| SCHEMBL28810508 | 0.72 | ALDH1A1 (0.36) | MAPTNPC1RAB9AMMP13 | |
| SCHEMBL2818990 | 0.70 | MAPT (0.42) | MAPTNPC1RAB9AKDM1AHRH3 | |
| SCHEMBL1703731 | 0.70 | MAPT (0.38) | MAPTNPC1RAB9AHRH3FPR2 | |
| SCHEMBL13547516 | 0.70 | MAPT (0.53) | MAPTNPC1RAB9AKDM1AFPR2 | |
| SCHEMBL8280912 | 0.70 | HRH3 (0.63) | MAPTNPC1RAB9AHRH3FPR2 | |
| SCHEMBL2642294 | 0.69 | MAPT (0.51) | MAPTNPC1RAB9AKDM1AFPR2 | |
| SCHEMBL9926020 | 0.69 | MAPT (0.51) | MAPTNPC1RAB9AKDM1AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903378-B | Aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD | 2014-03-12 | — | — | CN | claimed |
| CN-101903378-B | Aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD | 2014-03-12 | — | — | CN | disclosed |