Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28808532 | 0.99 | LRRK2 (0.42) | LRRK2PIK3CGPIK3CDSIGMAR1MAP4K4 | |
| SCHEMBL28406676 | 0.73 | ADK (0.50) | PIK3CGPIK3CDMAP4K4SRCRET | |
| SCHEMBL682467 | 0.66 | PIK3CD (0.56) | PIK3CGPIK3CDMAP4K4PIK3C2BSRC | |
| SCHEMBL13717458 | 0.66 | JAK3 (0.45) | LRRK2MAP4K4ALDH1A1LMNA | |
| SCHEMBL681842 | 0.65 | PIK3CG (0.67) | PIK3CGPIK3CDPIK3C2BALDH1A1 | |
| SCHEMBL20145916 | 0.64 | RPS6KB1 (0.47) | MAP4K4ALDH1A1LMNAPKM | |
| SCHEMBL4389982 | 0.64 | ALDH1A1 (0.57) | MAP4K4ALDH1A1LMNAPKM | |
| SCHEMBL1441357 | 0.64 | JAK3 (0.44) | LRRK2MAP4K4ALDH1A1LMNA | |
| SCHEMBL9159049 | 0.62 | HTT (0.61) | LRRK2ALDH1A1LMNAPKM | |
| SCHEMBL23917258 | 0.62 | JAK3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103702989-A | Novel compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA | 2014-04-02 | — | — | CN | claimed |
| CN-103702989-A | Novel compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA | 2014-04-02 | — | — | CN | disclosed |