Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.46 |
| ▸ | DRD3 | P35462 | 8/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943403 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL14060737 | 0.76 | CYP1A2 (0.43) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL28028576 | 0.73 | ALDH1A1 (0.38) | KDM4EMAPTABL1NPC1ALDH1A1 | |
| SCHEMBL28029000 | 0.72 | DRD2 (0.46) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL27943408 | 0.71 | DRD2 (0.45) | DRD2DRD3KDM4EMAPTRAD52 | |
| SCHEMBL27953748 | 0.68 | CYP1A2 (0.46) | DRD2DRD3KDM4EMAPTRAD52 | |
| SCHEMBL27953737 | 0.68 | ADRB1 (0.49) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL27770513 | 0.67 | DRD2 (0.43) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL424507 | 0.65 | DRD2 (0.75) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL3399254 | 0.64 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209463-A | 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors | ALMAC DISCOVERY LTD | 2015-12-30 | — | — | CN | claimed |
| CN-105209463-A | 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors | ALMAC DISCOVERY LTD | 2015-12-30 | — | — | CN | disclosed |