Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27959330 | 1.00 | LMNA (0.43) | LMNAKDM4EMAPTPDGFRBFGFR1 | |
| SCHEMBL27959334 | 0.83 | SIRT6 (0.50) | LMNAPDGFRBFGFR1KDRKCNH2 | |
| SCHEMBL27959335 | 0.83 | SIRT6 (0.50) | LMNAPDGFRBFGFR1KDRKCNH2 | |
| SCHEMBL28084589 | 0.75 | PTGER2 (0.40) | KDM4EMAPTPDGFRBFGFR1KDR | |
| SCHEMBL28084590 | 0.75 | PTGER2 (0.40) | KDM4EMAPTPDGFRBFGFR1KDR | |
| SCHEMBL27794794 | 0.72 | HRH3 (0.43) | LMNAKCNH2ALDH1A1KMT2AHDAC1 | |
| SCHEMBL521039 | 0.71 | MAPT (0.62) | LMNAKDM4EMAPTKCNH2GAA | |
| SCHEMBL25416662 | 0.70 | ALDH1A1 (0.42) | KDM4EMAPTGAAGFERALDH1A1 | |
| SCHEMBL30912518 | 0.70 | ALDH1A1 (0.42) | KDM4EMAPTGAAGFERALDH1A1 | |
| SCHEMBL30912507 | 0.70 | ALDH1A1 (0.42) | KDM4EMAPTGAAGFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103848814-B | The full ketone derivatives of substituted indole as tyrosine kinase inhibitor | 山东亨利医药科技有限责任公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103848814-A | Substituted indole ketone derivative as tyrosine kinase inhibitor | KBP BIOSCIENCES CO LTD | 2014-06-11 | — | — | CN | disclosed |