Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | LIPE | Q05469 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894256 | 0.94 | HTR1A (0.67) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL27714342 | 0.93 | HTR1A (0.65) | HTR1ADRD2GAAPTGER1PTGER4 | |
| Formaldehyde SCHEMBL27699996 | 0.91 | HTR1A (0.62) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL7145344 | 0.83 | HTR1A (0.54) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL68571 | 0.83 | L3MBTL1 (0.69) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL15336495 | 0.82 | CARM1 (0.57) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL8283688 | 0.82 | ALDH1A1 (0.67) | HTR1ADRD2GAAL3MBTL1MAPT | |
| SCHEMBL31757965 | 0.82 | CFD (0.68) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL1007508 | 0.82 | CFD (0.68) | HTR1ADRD2GAAPTGER1PTGER4 | |
| SCHEMBL23259230 | 0.82 | HTR1A (0.56) | HTR1ADRD2GAAPTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103764689-A | Solid catalyst component for polymerization of olefin, catalyst for polymerization of olefin, and method for producing olefin polymer | TOHO TITANIUM CO LTD | 2014-04-30 | — | — | CN | disclosed |