Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707605 | 0.89 | HSD17B10 (0.33) | MAPK1PTGS1PTGS2KMT2AL3MBTL1 | |
| SCHEMBL8708452 | 0.79 | MT-CO2 (0.36) | PTGS1PTGS2KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL22308707 | 0.74 | ALDH1A1 (0.38) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL15391066 | 0.74 | MAPT (0.37) | PTGS2KMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL1662205 | 0.74 | MAPT (0.37) | PTGS2KMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL8706888 | 0.73 | PTGS2 (0.33) | MAPK1PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL5786719 | 0.72 | PTGS1 (0.45) | PTGS1PTGS2KMT2AALDH1A1HPGD | |
| SCHEMBL29137732 | 0.70 | PTGS1 (0.41) | MAPK1PTGS1PTGS2KMT2AL3MBTL1 | |
| SCHEMBL18148764 | 0.70 | PTK2 (0.44) | MAPK1KMT2AL3MBTL1MEN1HPGD | |
| SCHEMBL1662668 | 0.69 | MAPK1 (0.33) | MAPK1KMT2AL3MBTL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157297-A | PRMT5 inhibitors | 上海齐鲁制药研究中心有限公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2023001133-A1 | PRMT5 INHIBITOR | 上海齐鲁制药研究中心有限公司 | 2023-01-26 | — | — | WO | disclosed |
| WO-2023001133-A1 | PRMT5 INHIBITOR | 上海齐鲁制药研究中心有限公司 | 2023-01-26 | — | — | WO | disclosed |
| EP-3459953-B1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2021-06-30 | — | — | EP | disclosed |
| CN-109153681-B | Novel 5H-pyrrolo [2,3-d ] pyrimidin-6 (7H) -one derivatives | 大鹏药品工业株式会社 | 2021-06-04 | — | — | CN | disclosed |
| US-20190292190-A1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2019-09-26 | — | — | US | disclosed |
| EP-3459953-A1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2019-03-27 | — | — | EP | disclosed |
| US-20160152576-A9 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA, INC. (US) | 2016-06-02 | — | — | US | disclosed |
| US-20140148436-A1 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-8680114-B2 | AKT protein kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20100168123-A1 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2010-07-01 | — | — | US | disclosed |
| EP-1684694-A2 | AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050130954-A1 | Serine/threonine protein kinase inhibitors; hyperproliferative disorder or inflammatory conditions; e.g. 4-(4-(2-amino-3-(p-chlorophenyl)-propionyl)-piperazin-1-yl)-quinazoline | ARRAY BIOPHARMA INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005051304-A2 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |
| US-5783580-A | FUNGICIDES | SANDOZ, LTD. (CH) | 1998-07-21 | — | — | US | disclosed |
| US-5547919-A | CONTROLLING PHYTOPATHOGENIC FUNGI | SANDOZ LTD. (CH) | 1996-08-20 | — | — | US | disclosed |
| EP-0667343-A1 | Alpha-pyrimidinyl acrylic acid derivatives with fungicidal activity | SANDOZ LTD. (CH) | 1995-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168123-A1 | AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT3 | MAPK1 65/4885PTGS1 3828/4885PTGS2 4054/4885 |
| US-20140148436-A1 | AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT3 | MAPK1 65/4885PTGS1 3828/4885PTGS2 4054/4885 |
| US-20160152576-A9 | AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT3 | MAPK1 65/4885PTGS1 3828/4885PTGS2 4054/4885 |
| US-20050130954-A1 | Serine/threonine protein kinase inhibitors; hyperproliferative disorder or inflammatory conditions; e.g. 4-(4-(2-amino-3-(p-chlorophenyl)-propionyl)-piperazin-1-yl)-quinazoline | MTOR, CDK2, CLK2 | MAPK1 98/4885PTGS1 1928/4885PTGS2 2578/4885 |
| US-20190292190-A1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | RPS6KA1, RPS6KA3, MAPK9 | MAPK1 39/4885PTGS1 2012/4885PTGS2 2509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.