Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236801 | 0.71 | HRH3 (0.64) | CCR2LMNA | |
| SCHEMBL27974362 | 0.70 | HRH3 (0.36) | — | |
| SCHEMBL12096205 | 0.70 | ALDH1A1 (0.45) | HTTLMNA | |
| SCHEMBL2301903 | 0.69 | HSD11B1 (0.73) | — | |
| SCHEMBL4011082 | 0.68 | KCNH2 (0.47) | KCNJ1KCNH2PTGS2 | |
| SCHEMBL23645694 | 0.66 | ALDH1A1 (0.57) | KCNH2 | |
| SCHEMBL6324221 | 0.65 | HRH3 (0.55) | — | |
| SCHEMBL6324218 | 0.65 | HRH3 (0.55) | — | |
| SCHEMBL26620383 | 0.65 | ALDH1A1 (0.55) | KCNH2LMNA | |
| SCHEMBL24315834 | 0.64 | POLB (0.57) | HTTKCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101151244-B | Histamine H3 receptor agents, preparation and therapeutic uses | LILLY CO ELI | 2014-09-03 | — | — | CN | disclosed |